1.1.1.290 | physiological function |
the pdxB gene, encoding erythronate-4-phosphate dehydrogenase, is required for de novo vitamin B6 biosynthesis. Mutation in pdxB causes growth deficiency of Photorhabdus luminescens in nutrient-poor medium, which is restored under nutrient-rich conditions or by supplementation with pyridoxal 5'-phosphate. Supplementation with pyridoxal, pyridoxine, and pyridoxamine also restores the growth of the pdxB mutant. Supplementation with pyridoxal 5'-phosphate restores the virulence-deficient phenotype against Caenorhabditis elegans |
-, 739912 |