EC Number   |
General Information |
Reference |
|---|
   1.1.1.12 | evolution |
the enzyme belongs to a medium-chain dehydrogenase/reductase (MDR) superfamily and a subfamily of polyol dehydrogenase, PDH |
-, 738728 |
| 1.1.1.12 | evolution |
the enzyme belongs to the medium-chain dehydrogenase/reductase (MDR) superfamily and polyol dehydrogenase (PDH) subfamily. The enzyme contains the typical NAD+-binding motif GxGxxG of MDR family enzymes |
-, 761551 |
| 1.1.1.12 | malfunction |
disruption of the L-arabitol dehydrogenase encoding gene in Aspergillus tubingensis results in increased xylanase production. The xylanase overproducing phenotype is mainly caused by loss of ladA function, while improved xylanase production is mediated by XlnR |
-, 740218 |
| 1.1.1.12 | malfunction |
disruption of the L-arabitol dehydrogenase encoding gene in Aspergillus tubingensis results in increased xylanase production. The xylanase overproducing phenotype is mainly caused by loss of ladA function, while improved xylanase production is mediated by XlnR. The ladA locus is the direct cause of the increased xylanase activity of 3M-43, a pyrA mutant of 3M-43 |
740218 |
| 1.1.1.12 | metabolism |
the enzyme is involved in the L-arabinose catabolic pathway |
-, 740218 |
| 1.1.1.12 | metabolism |
Yarrowia lipolytica strain ATCC MYA-2613 has endogenous enzymes for D-xylose assimilation, but inefficient xylitol dehydrogenase causes Yarrowia lipolytica to assimilate xylose poorly. L-Arabitol dehydrogenase is the rate-limiting step responsible for poor arabinose utilization in Yarrowia lipolytica. Functional roles of native sugar-specific transporters for activating the dormant pentose metabolism in Yarrowia lipolytica, cryptic pentose metabolism and native L-arabinose assimilation pathway, overview. TRP6Yli and TRP22Yli are xylose-specific transporters in Yarrowia lipolytica. L-Arabinose is first reduced into L-arabitol by NAD(P)H-dependent arabinose reductase (ARD), which is then converted into L-xylulose by NAD(P)+-dependent arabitol dehydrogenase (ADH). L-Xylulose is then converted to D-xylitol by NAD(P)H-dependent xylulose reductase (XLR), which is further assimilated to D-xylulose-5-phosphate, a precursor for the pentose-phosphate pathway (PPP) |
-, 760394 |
| 1.1.1.12 | more |
homology modeling and docking of L-arabinitol in the substrate-binding pocket of HjLAD suggesting routes of hydride transfer, where the key amino acid residues comprise the core region, molecular dynamics, overview |
-, 740145 |
| 1.1.1.12 | more |
three-dimensional structure homology modelling, overview |
-, 739939 |
| 1.1.1.12 | more |
xylitol production of wild-type and mutant strains, overview |
-, 721913, 740772 |
| 1.1.1.12 | physiological function |
induction of gene expression of the alpha-L-arabinofuranosidase encoding genes abf1, abf2, and abf3 and also bxl1, which encodes a beta-xylosidase with a separate alpha-L-arabinofuranosidase domain and activity, by L-arabinitol is strongly enhanced in a DELTAlad1 strain lacking L-arabinitol dehydrogenase activity and severely impaired in an aldose reductase DELTAxyl1 strain, suggesting a cross talk between L-arabinitol and the aldose reductase XYL1 in alpha-L-arabinofuranosidase gene expression |
711877 |
