EC Number   |
General Information |
Reference  |
|---|
   6.2.1.45 | physiological function |
the enzyme (Uba6) initiates signal transduction by activating ubiquitin and the ubiquitin-like protein FAT10 in a two-step process involving sequential catalysis of adenylation and thioester bond formation |
767593 |
| 6.2.1.45 | malfunction |
impaired UBA1 activity in a range of neurodegenerative conditions, including Parkinson's disease, Alzheimer's disease, Huntington's disease and spinal muscular atrophy |
766918 |
| 6.2.1.45 | metabolism |
ubiquitin-activating enzyme E1, UBA1, functions at the apex of the enzymatic ubiquitylation cascade, catalysing ubiquitin activation. UBA1 is thus of fundamental importance to the modulation of ubiquitin homeostasis and to all downstream ubiquitylation-dependent cellular processes, including proteolysis through the ubiquitin-proteasome system and selective autophagy |
766918 |
| 6.2.1.45 | physiological function |
UBA1 is essential for autophagy in certain cell types |
766918 |
| 6.2.1.45 | physiological function |
the enzyme regulates the ubiquitin conjugation cascade |
766440 |
| 6.2.1.45 | evolution |
yeast Ub-activating enzyme E1 is a modular protein, evolved from small prokaryotic proteins, which had specific functions, and in E1 enzyme they form domains that work together as part of a big enzyme |
-, 760825 |
| 6.2.1.45 | malfunction |
a defect in the UBA1 gene results in detrimental effects on cell cycle progression, and deletion of the UBA1 gene is lethal to the organism |
-, 760825 |
| 6.2.1.45 | metabolism |
ubiquitin-activating enzyme (E1) is the first enzyme of the ubiquitination pathway and is required to activate ubiquitin |
-, 760825 |
| 6.2.1.45 | physiological function |
ubiquitin-activating enzyme (E1) is the first enzyme of the ubiquitination pathway and is required to activate ubiquitin. E1 along with other enzymes plays a role in the regulation of cell cycle proteins like histone H2A and p53, which are essential for cell cycling |
-, 760825 |
| 6.2.1.45 | physiological function |
ubiquitin-activating enzyme (E1) is the first enzyme of the ubiquitination pathway and is required to activate ubiquitin. The SCCH domain and to some extent the ubiquitin fold domain (UFD) apparently interfere with cellular functions such as survival under various stresses |
-, 760825 |
