EC Number   |
General Information |
Reference |
|---|
   6.2.1.45 | evolution |
5 amino acids and 8 bases are different in cDNA and DNA sequences of CrUBE1 between Wuzishatangju and Shatangju, respectively |
733931 |
| 6.2.1.45 | malfunction |
a defect in the UBA1 gene results in detrimental effects on cell cycle progression, and deletion of the UBA1 gene is lethal to the organism |
-, 760825 |
| 6.2.1.45 | physiological function |
a lysine 48-linked polyubiquitin chain, assembled upon an internal lysine residue of a substrate protein, becomes the principle signal for recognition and target degradation by the 26S proteasome. E1 is not only essential for the initial ATP-dependent activation of ubiquitin in the ubiquitin degradtion pathway, but also capable of the catalytic extension of the polyubiquitin chain on a mono-ubiquitinated substrate |
725376 |
| 6.2.1.45 | physiological function |
comparative proteomic analysis of wild-type and SAP domain-mutant Foot-and-mouth disease virus-infected porcine cells identifies the ubiquitin-activating enzyme UBE1 required for virus replication. Overexpression of the enzyme UBE1 enhances the replication of the virus, and knockdown of UBE1 decreases virus replication. te virus manipulates UBE1 for increased viral replication, and the SAP domain is involved in this process, overview |
734563 |
| 6.2.1.45 | more |
conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation. UBE1 uses Cys632 in the active site |
735013 |
| 6.2.1.45 | metabolism |
early pregnancy influences expression of STAT1, Mx1, IP-10 and UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep |
760342 |
| 6.2.1.45 | physiological function |
early pregnancy reduces expression of UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep |
760342 |
| 6.2.1.45 | physiological function |
enzyme E1 is an essential gene for parasite viability and is implicated in encystation.Enzyme overexpression greatly increases the encystation rate, indicating a relationship between E1 and Giardia differentiation |
-, 733043 |
| 6.2.1.45 | malfunction |
identification of loss-of-function mutations in the Drosophila ubiquitin activating enzyme, the most upstream enzyme in the ubiquitin pathway. Loss of only one functional copy of E1 caused a significant reduction in adult lifespan. Rare homozygous hypomorphic E1 mutants reach adulthood, but mutants exhibit further reduced lifespan and show inappropriate Ras activation in the brain. Removing just one functional copy of Ras restores the lifespan of heterozygous E1 mutants to that of wild-type flies and increase the survival of homozygous E1 mutants. E1 homozygous mutants also show severe motor impairment involved in early mortality. Phenotypes, detailed overview |
735079 |
| 6.2.1.45 | malfunction |
impaired UBA1 activity in a range of neurodegenerative conditions, including Parkinson's disease, Alzheimer's disease, Huntington's disease and spinal muscular atrophy |
766918 |
