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only a deletion mutant of PGM3, not of PGM1 or PGM2, hyperaccumulates ribose-1-phosphate, and shows a strongly increased concentration of ribose 1-phosphate and completely defective recycling of ribose 1-phosphate upon glucose-induced purine nucleoside recycling via the purine salvage pathway
the active site is located between two independently folded domains. The enzyme engages substrates when the active site nucleophile, Thr85, is phosphorylated
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