EC Number   |
General Information |
Reference |
|---|
    4.1.1.20 | metabolism |
binding of PLP initiates rearrangements within the active site, specifically the reorientation of Arg169, His218, and His22, which is propagated to the active-site loop, through Arg169. The substrate, meso-diaminopimelate, is positioned through interactions with conserved active-site residues to form an additional hydrogen bond to His220. This stabilizes the closed active-site loop conformation, mediated through Arg169, and can only occur when the D-stereocenter is oriented for decarboxylation |
772815 |
| 4.1.1.20 | metabolism |
diaminopimelate decarboxylase (DAPDC) catalyzes the conversion of meso-2,6-diaminopimelate to lysine and carbon dioxide in the final step of the diaminopimelate (DAP) pathway |
-, 747204 |
| 4.1.1.20 | metabolism |
enzyme meso-diaminopimelic acid decarboxylase (DAPDC) catalyzes the final step in the de novo L-lysine biosynthetic pathway by converting meso-diaminopimelic acid (meso-DAP) into L-lysine by decarboxylation reaction |
-, 747000 |
| 4.1.1.20 | metabolism |
the enzyme catalyzes the irreversible and stereospecific decarboxylation of meso-diaminopimelate (meso-DAP) in the final step of the diaminopimelate (DAP) biosynthesis pathway |
-, 748217 |
| 4.1.1.20 | more |
dimerization of bacterial diaminopimelate decarboxylase is essential for catalysis |
-, 748217 |
| 4.1.1.20 | physiological function |
expression of DAPDC1 rescues Escherichia coli that harbors a mutation in the gene encoding DAPDC. DAPDC1 is only able to rescue the mutant when its expression is repressed by glucose |
772815 |
| 4.1.1.20 | physiological function |
expression of DAPDC2 rescues Escherichia coli that harbors a mutation in the gene encoding DAPDC. DAPDC2 is only able to rescue the mutant when its expression is repressed by glucose |
772815 |
| 4.1.1.20 | physiological function |
the product of the reaction, L-lysine, is an important building block for the biosynthesis of the peptidoglycan cell wall, housekeeping proteins, and virulence factors of bacteria |
-, 748217 |
