EC Number   |
General Information  |
Reference |
|---|
   3.1.31.1 | evolution |
sequence comparison and phylogenetic analysis, Staphylococcus clustering, overview. The divergent Staphylococcus aureus clade harbors a homologue of the thermostable nuclease (NucM) whose nucleotide sequence is highly divergent from those of nuc1 and nuc2 of Staphylococcus aureus reference strains |
-, 730113 |
| 3.1.31.1 | malfunction |
conditioned medium from Hep3B-SND1 cells stably overexpressing SND1 augmentes, whereas that from QGYSND1si cells stably overexpressing SND1 siRNA significantly inhibits angiogenesis, as analyzed by a chicken chorioallantoic membrane assay and a human umbilical vein endothelial cell differentiation assay |
729981 |
| 3.1.31.1 | malfunction |
mutations of either or both of the nuclease genes nuc1 and nuc2 result in an enhanced capacity to form a biofilm, mutation of nuc2 also has an impact on the ability of a sarA mutant to form a biofilm, at least in the absence of coating with plasma proteins. The susceptibility to daptomycin is reduced in the mutants |
729819 |
| 3.1.31.1 | malfunction |
mutations of either or both of the nuclease genes nuc1 and nuc2 result in an enhanced capacity to form a biofilm. The susceptibility to daptomycin is reduced in the mutants |
-, 729819 |
| 3.1.31.1 | malfunction |
suppression of Penaeus monodon Tudor staphylococcal nuclease by double-stranded RNA results in decreasing dsRNA-mediated gene silencing activity. Knockdown of Argonaute protein PmAgo1 and the enzyme diminishes the ability of dsRNA-Rab7 to knockdown PmRab7 expression |
729764 |
| 3.1.31.1 | malfunction |
when the nuc1 gene is knocked out, the ability of Staphylococcus aureus strains to form a biofilm significantly increased |
-, 718396 |
| 3.1.31.1 | metabolism |
extracellular DNA promotes biofilm formation in Staphylococcus aureus and, conversely, extracellular nucleases limit the ability to form a biofilm |
-, 729819 |
| 3.1.31.1 | metabolism |
inhibition of NF-kappaB blocks enzyme-induced angiogenesis |
729981 |
| 3.1.31.1 | metabolism |
programmed cell death pathways, Tudor staphylococcal nuclease is a new component of the human programmed degradome and is cleaved by caspase-3 between the Tudor and SN5 domains |
705843 |
| 3.1.31.1 | metabolism |
programmed cell death, enzyme is a part of the stress-induced cell-death degradome during both developmental and stress-induced cell deaths |
705843 |
