EC Number   |
General Information |
Reference  |
|---|
   2.8.2.30 | physiological function |
the enzyme is a epithelial-mesenchymal transition inducer in pancreatic cancer. Overexpression of isoform 3-OST-3B1 upregulates Snail expression and triggers its nuclear translocation. The enzyme promotes in vivo angiogenic response |
724692 |
| 2.8.2.30 | physiological function |
CHO-K1 cells expressing 3-OST-3 isoform induce membrane protrusions during herpes simplex virus type-1 entry. Enzyme expression is associated with enhanced filopodia induction |
726083 |
| 2.8.2.30 | physiological function |
heparan sulfate proteoglycans modified by zebrafish encoded glucosaminyl 3-O sulfotransferase-3 generate a receptor for herpes simplex virus type-1 entry and spread |
726083 |
| 2.8.2.30 | physiological function |
the enzyme shows a potent inhibitory effect on hepatitis B virus replication and protein expression |
726527 |
| 2.8.2.30 | malfunction |
knocking down enzyme receptor in fibroblasts cells significantly reduces HSV-1 entry and glycoprotein D binding to cells |
726544 |
| 2.8.2.30 | physiological function |
3-O-sulfotransferase-3 isoform mediates Herpes simplex virus type 1 entry and spread |
726544 |
| 2.8.2.30 | physiological function |
the enzyme is involved in bone marrow mesenchymal stromal cell differentiation |
737733 |
| 2.8.2.30 | physiological function |
isoform HS3ST3B1 positively contributes to acute myeloid leukemia progression. The enzyme increases vascular endothelial growth factor expression and release by leukemia cells and promotes the activation of the Notch-1-Jagged-1, PI3K-AKT and ERK pathways |
738745 |
| 2.8.2.30 | physiological function |
isoform 3-OST-3 mediates herpes simplex virus-1 entry and spread |
738938 |
| 2.8.2.30 | physiological function |
3-OST3A exerts dual activities acting as tumor-suppressor in MCF-7 and MDA-MB-231 cells, or as an oncogenic factor in SKBR-3 cells |
739207 |
