EC Number   |
General Information |
Reference |
|---|
   2.8.2.30 | physiological function |
3-O-sulfotransferase-3 isoform mediates Herpes simplex virus type 1 entry and spread |
726544 |
| 2.8.2.30 | physiological function |
3-OST3A exerts dual activities acting as tumor-suppressor in MCF-7 and MDA-MB-231 cells, or as an oncogenic factor in SKBR-3 cells |
739207 |
| 2.8.2.30 | evolution |
both isozymes, HS3ST3B and HS3ST2 (EC 2.8.2.29), are differently expressed in monocytes and macrophages depending on the inflammatory environment |
760623 |
| 2.8.2.30 | physiological function |
CHO-K1 cells expressing 3-OST-3 isoform induce membrane protrusions during herpes simplex virus type-1 entry. Enzyme expression is associated with enhanced filopodia induction |
726083 |
| 2.8.2.30 | malfunction |
enhanced 3-O-sulfation increases binding to antithrombin, which enhances Factor Xa inhibition, and binding of neuropilin-1 |
762294 |
| 2.8.2.30 | malfunction |
expression of the genes encoding HS-modifying enzymes is frequently dysregulated in cancer and other diseases. The enzymes show either anti-oncogenic or tumor-promoting effects. Hypermethylation in proximal regions of the HS3ST3A1 gene in chondrosarcoma. Exposure to a demethylating agent restores its expression, confirming that aberrant methylation has affected its transcription. Re-expression of HS3ST3A reduces the proliferative and migratory properties of chondrosarcoma cells, suggesting that silencing of this enzyme may have contributed to tumor cell growth and invasiveness. The HS3ST3A1 gene is epigenetically repressed in breast cancer cell lines representative of the different molecular subgroups, except in the human epidermal growth factor receptor 2-positive (HER2+) cell lines. Re-expression of the enzyme in luminal A-type MCF-7 and triple negative MDA-MB-231 cell lines reduces cell proliferation in vitro. HS3ST3A is also anti-proliferative in MDA-MB-231 cells. Overexpression of HS3ST3A does not have any effects on the proliferation of MDA-MB-231 cells |
761164 |
| 2.8.2.30 | malfunction |
expression of the genes encoding HS-modifying enzymes is frequently dysregulated in cancer and other diseases. The enzymes show either anti-oncogenic or tumor-promoting effects. Re-expression of HS3ST3B in MDA-MB-231 cells leads to an increase in cell viability and invasion, MDA-MB-231 cells carrying HS3ST3B expression display a significant increase in proliferation and survival. High expression of HS3ST3B in U937 leukemia cells enhances cell proliferation and survival, while its silencing has opposite effects |
761164 |
| 2.8.2.30 | metabolism |
heparan sulfate (HS) 3-O-sulfation can be catalysed by seven 3-sulfotransferases (HS3STs) in humans, but nevertheless it is the rarest modification in heparan sulfate (HS). Isozymes HS3ST2 (EC 2.8.2.29) and HS3ST3B exhibit the same activity in vitro. But they are differently expressed in macrophages depending on cell environment, which suggests that they may be involved in distinct cellular processes |
760623 |
| 2.8.2.30 | metabolism |
heparan sulfate (HS) is a type of glycosaminoglycan consisting of variably sulfated glucuronic acid or iduronic acid-Nacetylglucosamine repeating disaccharide units, and it can bind plenty of growth factors such as FGF2 and its receptor FGFR1, thereby regulating cancer cell signaling. Divergent fine structures of HS are generated by sulfation catalyzed by HS Ndeacetylase/N-, 2-O-, 6-O-, 3-O-sulfotransferases (correspondingly abbreviated as NDST, HS2ST, HS6ST, HS3ST), epimerization catalyzed by HS C5-epimerase at the Golgi lumen and further desulfation catalyzed by HS 6-O-endosulfatase at the cell surface. There are several isoforms in every gene family except that HS2ST gene family has only one isoform |
761220 |
| 2.8.2.30 | physiological function |
heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) participates in the biosynthetic steps of heparan sulfate (HS) and targets vascular endothelial growth factor (VEGF) in acute myeloid leukemia (AML) cells, thus contributing to angiogenesis and proliferation of AML cells. HS3ST3B1 plays a role in angiogenesis and the proliferation of cancer cells. Heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1 is a regulator of transforming growth factor-beta-mediated epithelial-to-mesenchymal transition and regulated by miR-218 in nonsmall cell lung cancer |
761577 |
