EC Number |
General Information |
Reference |
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2.5.1.21 | evolution |
phylogenetic analysis of SQS enzymes in plants shows highly similar conserved pattern including 77DTVED81 and 213DYLED217 motifs, which are rich in aspartic acids involved in FPP binding |
739735 |
2.5.1.21 | evolution |
the enzyme belongs to the isoprenoid biosynthesis enzymes class 1 superfamily |
-, 738798 |
2.5.1.21 | malfunction |
enzyme overexpression in transgenic Withania somnifera plants affects the shoot elongation and multiplication, phenotype, overview |
739290 |
2.5.1.21 | malfunction |
Inhibition of squalene synthase leads directly to a reduction in cholesterol biosynthesis and thus to a fall in plasma cholesterol levels. Plasma LDL-cholesterol and triglycerides are lowered by squalene synthase inhibitors |
721802 |
2.5.1.21 | malfunction |
modifications in region IV prevents SQS from undergoing the second half-reaction, indicating that this region may reasonably constitute a functional NADPH binding site |
722759 |
2.5.1.21 | malfunction |
the SQS inhibitors YM-53601 and zaragozic acid A decrease hepatitis C virus RNA, protein, and progeny production in HCV-infected cells without affecting cell viability, using the HCV JFH-1 strain and human hepatoma Huh-7.5.1-derived cells. siRNA-mediated knockdown of SQS leads to significantly reduced HCV production, confirming the enzyme acts as an antiviral target. A metabolic labeling study demonstrates that enzyme inhibitor YM-53601 suppresses the biosynthesis of cholesterol and cholesteryl esters at antiviral concentrations |
738940 |
2.5.1.21 | metabolism |
enzyme SQS operates at a branch point of the withanolide biosynthetic pathway regulating the metabolic flux and catalyzes the first committed step leading to the synthesis of different withanolides |
739290 |
2.5.1.21 | metabolism |
four major steps - substrate binding, condensation, intermediate formation and translocation - of the ordered sequential mechanisms involved in the 1'-1 isoprenoid biosynthetic pathway |
737345 |
2.5.1.21 | metabolism |
key enzyme in the isoprenoid pathway |
706801 |
2.5.1.21 | metabolism |
part of cholesterol biosynthesis pathway |
703278 |