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Results 1 - 10 of 51 > >>
EC Number General Information Commentary Reference
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21evolution phylogenetic analysis of SQS enzymes in plants shows highly similar conserved pattern including 77DTVED81 and 213DYLED217 motifs, which are rich in aspartic acids involved in FPP binding 739735
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21evolution the enzyme belongs to the isoprenoid biosynthesis enzymes class 1 superfamily -, 738798
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21malfunction enzyme overexpression in transgenic Withania somnifera plants affects the shoot elongation and multiplication, phenotype, overview 739290
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21malfunction Inhibition of squalene synthase leads directly to a reduction in cholesterol biosynthesis and thus to a fall in plasma cholesterol levels. Plasma LDL-cholesterol and triglycerides are lowered by squalene synthase inhibitors 721802
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21malfunction modifications in region IV prevents SQS from undergoing the second half-reaction, indicating that this region may reasonably constitute a functional NADPH binding site 722759
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21malfunction the SQS inhibitors YM-53601 and zaragozic acid A decrease hepatitis C virus RNA, protein, and progeny production in HCV-infected cells without affecting cell viability, using the HCV JFH-1 strain and human hepatoma Huh-7.5.1-derived cells. siRNA-mediated knockdown of SQS leads to significantly reduced HCV production, confirming the enzyme acts as an antiviral target. A metabolic labeling study demonstrates that enzyme inhibitor YM-53601 suppresses the biosynthesis of cholesterol and cholesteryl esters at antiviral concentrations 738940
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21metabolism enzyme SQS operates at a branch point of the withanolide biosynthetic pathway regulating the metabolic flux and catalyzes the first committed step leading to the synthesis of different withanolides 739290
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21metabolism four major steps - substrate binding, condensation, intermediate formation and translocation - of the ordered sequential mechanisms involved in the 1'-1 isoprenoid biosynthetic pathway 737345
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21metabolism key enzyme in the isoprenoid pathway 706801
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21metabolism part of cholesterol biosynthesis pathway 703278
Results 1 - 10 of 51 > >>