EC Number   |
General Information |
Reference |
|---|
    2.5.1.21 | more |
determination and analysis of human SQS and its mutants in complex with several substrate analogues and intermediates coordinated with Mg2+ or Mn2+, SQS active analysis, overview |
737345 |
| 2.5.1.21 | malfunction |
enzyme overexpression in transgenic Withania somnifera plants affects the shoot elongation and multiplication, phenotype, overview |
739290 |
| 2.5.1.21 | more |
enzyme overexpression leads a significant 4fold enhancement in squalene synthase activity and 2.5fold enhancement in withanolide A content, transformed cell suspension cultures also produce withaferin A, which is absent in the non-transformed cell cultures |
722843 |
| 2.5.1.21 | metabolism |
enzyme SQS operates at a branch point of the withanolide biosynthetic pathway regulating the metabolic flux and catalyzes the first committed step leading to the synthesis of different withanolides |
739290 |
| 2.5.1.21 | physiological function |
enzyme SQS plays an important role in regulating isoprenoid biosynthesis in eukaryotes |
738856 |
| 2.5.1.21 | physiological function |
essential role in embryonic development |
703278 |
| 2.5.1.21 | metabolism |
four major steps - substrate binding, condensation, intermediate formation and translocation - of the ordered sequential mechanisms involved in the 1'-1 isoprenoid biosynthetic pathway |
737345 |
| 2.5.1.21 | more |
functional analyses of the enzyme's two DXXD(E)D motifs and the highly conserved aromatic amino acid residues, kinetic analysis and reaction mechanism, overview. The potential active-site residues 58DXX61E62D (S1 site) and 213DXX216D217D (S2 site) are assumed to be involved in the binding of the substrate farnesyl diphosphate through the Mg2+ ion. The S1 site and the two basic residues R55 and K212 are responsible for the binding of farnesyl diphosphate |
738214 |
| 2.5.1.21 | more |
homology modelling of SQS enzyme of Withania somnifera for the prediction of three-dimensional structure, molecular docking study of considered substrates, overview |
739037 |
| 2.5.1.21 | physiological function |
influence on regulation of cholesterol metabolism |
697143 |
