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EC Number	General Information	Commentary	Reference
2.4.2.17	metabolism	essential for histidine biosynthesis	721765
2.4.2.17	metabolism	the enzyme catalyzes the first step of histidine biosynthesis	776287
2.4.2.17	metabolism	the enzyme catalyzes the first step of histidine biosynthesis and is controlled via a complex allosteric mechanism where the regulatory protein HisZ enhances catalysis by the catalytic protein HisGS while mediating allosteric inhibition by histidine	-, 778695
2.4.2.17	physiological function	subunit HisGS is necessary for the bacterium to persist in the lung during pneumonia	776287

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Release 2026.1 (March 2026)