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Results 1 - 9 of 9
EC Number
General Information
Commentary
Reference
evolution
HaSCP-x/SCP-2 is a member of the SCP-2 gene family
evolution
the MsSCP-x/SCP-2 protein has a high degree of homology in the SCP-2 domain to other insect SCP-2; the MsSCP-x/SCP-2 protein has a high degree of homology in the SCP-2 domain to other insect SCP-2
more
effects of dsRNA interference of HaSCP-x/SCP-2 transcripts on larval development and fecundity in adults, overview
physiological function
HaSCPx/2 gene is important for normal development and fertility in Helicoverpa armigera
physiological function
inhibitor-treated larvae at young stage show a significant decrease of cholesterol uptake in vivo
physiological function
knockdown of scp2 does not interfere with the patterning of the kidney along its proximo-distal axis, but dramatically decreases the size of the kidney, in particular the proximal tubules. This phenotype is accompanied by a reduction of lipid rafts, but is independent of the peroxisomal or transcriptional activities of scp2. Disrupting lipid microdomains by inhibiting cholesterol synthesis phenocopies the defects seen in scp2 morphants
physiological function
MsSCP-2 may function as a lipid carrier protein in vivo, MsSCP-2 is involved in cholesterol uptake in vivo, overview
physiological function
overexpression enhances cholesterol uptakeinto Spli-221 cells
physiological function
SCP2 is a binding protein for endocannbinoids N-arachidonylethanolamine and 2-arachidonoylglycerol. N-arachidonylethanolamine and 2-arachidonoylglycerol associate with SCP2 at a putative cholesterol binding pocket with DeltaG values of -3.6 and -4.6 kcal per mol, respectively. SCP2-mediated transfer of cholesterol in vitro is inhibited by micromolar concentrations of N-arachidonylethanolamine, and heterologous expression of SCP2 in HEK-293 cells increases time-related accumulation of N-arachidonylethanolamine in a temperature-dependent fashion
Results 1 - 9 of 9