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Results 1 - 9 of 9
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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67evolution Callithrix jacchus thiopurine S-methyltransferase (TPMT) is phylogenetically closer to other primate orthologs than to its pig, dog, rabbit, or rodent orthologs 777173
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67evolution Callithrix jacchus thiopurine S-methyltransferase (TPMT) is phylogenetically closer to other primate orthologs than to its pig, dog, rabbit, or rodent orthologs. Callithrix jacchus and human TPMT are similar at the molecular level 777173
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67malfunction intermediate and low enzyme activity may lead to leukopenia following thiopurine treatment 733706
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67malfunction when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure 720847
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67metabolism thiopurine drugs, azathioprine, mercaptopurine, and thioguanine, are widely used in the treatment of several malignant and nonmalignant diseases. Patients with low-activity variants of thiopurine S-methyltransferase can be affected by pronounced pharmacologic effects when receiving thiopurine medications 778459
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67more a method used to determine thiopurine S-methyltransferase activity by measuring 6-MMP by liquid chromatography-tandem mass spectrometry while employing 6-methylmercaptopurine-d3 as an internal standard 778459
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67more the enzyme plays roles in the metabolism of widely used anticancer and anti-inflammatory drugs 777173
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67physiological function both thiopurine S-methyltransferase (TPMT) and indolethylamine N-methyltransferase (INMT) cooperatively contributed to the trimethylselenonium ion production, enabling urinary excretion of Se and maintenance of homeostasis of this essential yet highly toxic trace element. Thus, TPMT and INMT can be recognized as selenium methyltransferases 777027
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67physiological function thiopurine S-methyltransferase and indolethylamine N-methyltransferase are cooperatively responsible for the detoxification of Tellurium oxyanions through methylation to form trimethyltelluronium ions 776531
Results 1 - 9 of 9
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