EC Number   |
General Information |
Reference |
|---|
    2.1.1.355 | drug target |
HF6 recruits methyltransferase SUV39H1 to the nucleolar region in leukemia and provids a potential therapeutic target for PHF6-mutant leukemia |
776356 |
| 2.1.1.355 | drug target |
pharmacological inhibition of SUV39H1 is an effective approach to suppress human colorectal carcinoma |
776901 |
| 2.1.1.355 | evolution |
protein BLAST analyses shows that Dim5 orthologues are widely distributed amongst filamentous Trichoderma, Penicillium, Fusarium, Neurospora and Aspergillus species, although they exhibit different amino acid lengths. To analyse the phylogenetic relationship between Dim5 homologues from filamentous fungi and SpClr4, a phylogenetic tree is built using Dim5 orthologues from this species as well as SpClr4. Filamentous fungi Dim5 orthologues form two distinct clusters from SpClr4. Amongst them, Trichoderma Dim5 shows a close evolutionary relationship with the orthologues from Fusarium and Neurospora species |
-, 778461 |
| 2.1.1.355 | malfunction |
an enzyme deletion mutant shows significant defects in conidiation, perithecium production and fungal virulence. Enzyme deletion results in increased tolerance to osmotic stresses and upregulated Hog1 phosphorylation |
-, 753592 |
| 2.1.1.355 | malfunction |
deletion of the clr4 gene eliminates H3K9me2/me3 but not H3K9me1, indicating the presence of another protein capable of monomethylating H3K9 |
-, 776699 |
| 2.1.1.355 | malfunction |
during oxidative stress exposure, enzyme mutants show overactivation of stress response genes, rapid depletion of glycogen, and inability to access lipid energy stores |
755057 |
| 2.1.1.355 | malfunction |
dysregulation of SUV39H1 is observed in different cancers |
778395 |
| 2.1.1.355 | malfunction |
embryonic stem cells lacking the H3K9 HMTase G9a show a significant reduction in DNA methylation of retrotransposons, major satellite repeats and densely methylated CpG-rich promoters |
703442 |
| 2.1.1.355 | malfunction |
enzyme depletion results in embryonic lethality with severe differentiation defects in embryonic stem cells. Enzyme depletion inhibits cell proliferation in several cancer cell lines |
753662 |
| 2.1.1.355 | malfunction |
enzyme inhibition attenuates oncogenicity and activates the hypoxia signaling pathway |
755156 |
