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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224physiological function the Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics 701724
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224physiological function cfr confers combined resistance to chloramphenicol, florfenicol and clindamycin 705766
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224evolution bioinformatics analysis of the Cfr/RlmN family establishes their significant evolutionary link with radical-S-adenosyl-L-methionine enzymes. The RlmN subfamily is likely the ancestral form, whereas the Cfr subfamily arose via duplication and horizontal gene transfer 705983
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224physiological function Cfr confers a phenotype with resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics. The RlmN knock out strain JW2501-1 is less sensitive to the antibiotics than standard laboratory strain HB101 706726
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224more acquisition of the cfr gene does not produce any appreciable reduction in the cell growth rate, analysis of fitness cost of cfr expression, overview. Genes ermB and cfr are coexpressed under the Perm promoter in the mlr operon. Dimethylation of A2058 by the Erm methyltransferase increases the fitness cost associated with Cfr-mediated modification of A2503 -, 718587
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224physiological function rRNA methyltransferase Cfr that methylates the conserved 23S rRNA residue A2503, located in a functionally critical region of the ribosome, confers resistance to an array of ribosomal antibiotics, including linezolid -, 718587
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224evolution ClbA acts via the same mechanism as the Cfr methyltransferase -, 718601
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224evolution ClbB acts via the same mechanism as the Cfr methyltransferase -, 718601
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224evolution ClbC acts via the same mechanism as the Cfr methyltransferase 718601
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.224physiological function ClbA confers resistance to antibiotics, florfenicol, clindamycin, linezolid, tiamulin, and streptogramin A/streptogramin B, to the cell, also when expressed in Escherichia coli strain AS19, overview -, 718601
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