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Reference
physiological function
Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant
physiological function
Cyp128 is the enzyme responsible for the terminal oxidation of the polyisoprenoid chain of dihydromenaquinone-9, thereby allowing sulfation of the resulting hydroxyl moiety by Stf3. The sulfated metabolite S881 is associated with virulence in Mycobacterium tuberculosis
Results 1 - 2 of 2