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EC Number
General Information
Commentary
Reference
malfunction
inactivation of the enzyme in promastigotes results in disruption of the membrane stability, increase of membrane fluidity, failure to maintain lipid rafts, and hypersensitivity to heat stress along with altered morphology and cytokinesis defect. The effect deletion on lipid composition and sterol biosynthesis is a complete loss of ergostane-based sterols (5-dehydroepisterol, ergosterol, and episterol) and accumulation of toxic 14-methylated sterols
metabolism
key enzyme in the synthesis of ergosterol, an essential component of the fungal cell membrane
metabolism
the enzyme is required for synthesis of cholesterol and other sterols in mammals
physiological function
key enzyme in the synthesis of ergosterol, an essential component of the fungal cell membrane
physiological function
the enzyme is required for effective survival, normal proliferation and infectivity of Leishmania major parasites in the mammalian host. The enzyme is not required for promastigote survival or proliferation, but it is involved in the control of cell shape, differentiation, and division
Results 1 - 5 of 5