EC Number   |
General Information |
Reference  |
|---|
   1.13.99.1 | physiological function |
biological production of glucaric acid |
695783 |
| 1.13.99.1 | physiological function |
start of catabolism of carbon skeleton of cell-signaling inositol polyphosphates and phosphoinositides |
697532 |
| 1.13.99.1 | malfunction |
increased expression in diabetic kidneys may contribute to tubulointerstitial injury and development of diabetic nephropathy |
697793 |
| 1.13.99.1 | physiological function |
control level of myoinositol, no influence on ascorbic acid |
700818 |
| 1.13.99.1 | metabolism |
MIOX is the first and rate-limiting enzyme in myo-inositol metabolism pathway |
712593 |
| 1.13.99.1 | more |
increase in MIOX enzyme activity is in proportion to serum glucose concentrations and may be responsible for the myo-inositol depletion found in the type I diabetes mellitus complications, detailed phenotype analysis of 130 Caucasian patients, overview |
712593 |
| 1.13.99.1 | malfunction |
loss-of-function mutants in MIOX genes contain alterations in myo-inositol levels and growth changes in the root |
727579 |
| 1.13.99.1 | malfunction |
loss-of-function mutants in MIOX genes contain alterations in myo-inositol levels and growth changes in the root. Miox2 mutants can be complemented with a MIOX2:green fluorescent protein fusion |
727579 |
| 1.13.99.1 | malfunction |
a quadruple (miox1/2/4/5) mutant that incorporates T-DNA insertions in all four MIOX genes is generated. This mutant shows a severe reduction in transcripts for all four MIOX genes. The quadruple myo-inositol oxygenase mutant shows a significant reduction in susceptibility to Heterodera schachtii, and syncytia have elevated myo-inositol and galactinol levels and an elevated expression level of the antimicrobial thionin gene Thi2.1 |
728381 |
| 1.13.99.1 | physiological function |
the importance of MIOX in syncytium development is the removal of excess myo-inositol from syncytia |
728381 |
