EC Number   |
General Information |
Reference |
|---|
   6.2.1.45 | metabolism |
early pregnancy influences expression of STAT1, Mx1, IP-10 and UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep |
760342 |
| 6.2.1.45 | metabolism |
the ubiquitin E1 activating enzyme ubiquitin-activating enzyme 1 (UBE1) is a putative substrate of FAT10. The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directly targets its substrates for proteasomal degradation by becoming covalently attached via its C-terminal diglycine motif to internal lysine residues of its substrate proteins. UBE1 and FAT10 formed a stable isopeptide linkage. The conjugation machinery consists of the bispecific E1 activating enzyme ubiquitin-like modifier activating enzyme 6 (UBA6), the likewise bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1 (USE1), and possibly E3 ligases, overview. UBE1 and FAT10 form a stable non-reducible conjugate, FAT10ylation of UBE1 depends on the diglycine motif of FAT10 |
735013 |
| 6.2.1.45 | metabolism |
the ubiquitin-activating enzyme E1 (UBA1, E1) is the apex of the ubiquitin proteasome pathway |
744190 |
| 6.2.1.45 | metabolism |
ubiquitin-activating enzyme (E1) is the first enzyme of the ubiquitination pathway and is required to activate ubiquitin |
-, 760825 |
| 6.2.1.45 | metabolism |
ubiquitin-activating enzyme E1 catalyzes the first step in the ubiquitination reaction, which targets a protein for degradation via a proteasome pathway. The enzyme plays an important role in metabolic processes |
733931 |
| 6.2.1.45 | metabolism |
ubiquitin-activating enzyme E1, UBA1, functions at the apex of the enzymatic ubiquitylation cascade, catalysing ubiquitin activation. UBA1 is thus of fundamental importance to the modulation of ubiquitin homeostasis and to all downstream ubiquitylation-dependent cellular processes, including proteolysis through the ubiquitin-proteasome system and selective autophagy |
766918 |
| 6.2.1.45 | more |
conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation. UBE1 uses Cys632 in the active site |
735013 |
| 6.2.1.45 | more |
sequence and structure comparisons, overview |
733532 |
| 6.2.1.45 | more |
the enzyme has six ATP binding sites, one catalytic residue, and one E2 binding domain |
733931 |
| 6.2.1.45 | more |
UBA5 is the smallest and structurally simplest E1. The active site Cys of UBA5 (Cys 250) is located within the adenylation domain, but this domain is not sufficient for the formation of a thioester bond between the UFM1 C terminus and the UBA5 catalytic Cys. Modeling of a cis-binding mechanism of UFM1 to UBA5. Trans-binding mechanism of UFM1 transfer to the E2, UFC1. Homodimerization of UBA5 is essential for activating UFM1 |
744655 |
