EC Number   |
Expression |
Reference |
|---|
    2.4.2.26 | down |
SW1353 cells treated with curcumin (0.02 mM) and tanshinone IIA (0.1 mM), respectively, for 6 h show significantly reduced XT-I mRNA expression to 41.8% and 13.8%, respectively. SW1353 cells treated with different concentrations (10 nM to 0.001 mM) of mithramycin A for 24 h show a highly significant decrease of XT-I mRNA levels compared with nontreated cells. mRNA level of both specificity protein 1 and specificity protein 3 is significantly reduced to less than 30% compared with controls treated with a scrambled siRNA for a total of 96 h after transfection. The siRNA-mediated knockdown of specificity protein 1 has no detectable effect on the XT-I mRNA levels, whereas the knockdown of specificity protein 3 leads to a highly significant reduction to ca. 40% compared with controls. Decrease of 51% in the enzyme xylosyltransferase activity in the cell culture supernatant of specificity protein 3 siRNA-transfected cells compared with controls 96 h after transfection |
704560 |
| 2.4.2.26 | down |
XT-I gene expression is down-regulated by IL-1beta |
723555, 723642 |
| 2.4.2.26 | up |
members of the activator protein 1 and specificity protein 1 family of transcription factors are necessary for the transcriptional regulation of the XYLT1 gene. Transcription factors of the specificity protein 1 family, especially specificity protein 3, are very likely involved in the regulation of the XT-I mRNA expression. A 531-bp core promoter element is able to drive the transcription on a basal level. A binding site for transcription factors of the activator protein 1 family, which is essential for full promoter activity is located 730 bp 5' of the translation initiation site. A promoter element containing this binding site is able to drive the transcription to about 79fold above control in SW1353 chondrosarcoma cells |
704560 |
| 2.4.2.26 | up |
XT-I gene expression is up-regulated by TGF-beta1 |
723555, 723642 |
