EC Number   |
Expression |
Reference |
|---|
   2.4.1.144 | down |
downregulation of GnT-III expression in MDA-MB-231 cells, an E-cadherin-deficient cell line, the MDCK cell, in which GnTIII expression is undetectable, and fibroblasts, which lack E-cadherin |
705381 |
| 2.4.1.144 | down |
during epithelial-mesenchymal-transition, enzyme expression is dramatically decreased and later recoveres when cells return to an epithelial-like phenotype |
723551 |
| 2.4.1.144 | down |
GnT-III knockdown in MCF-7/AZ cells through siRNA |
703956 |
| 2.4.1.144 | down |
in MDA-MB231 cells, an E-cadherin-deficient cell line, GnT-III expression is undetectable |
702516 |
| 2.4.1.144 | down |
knockdown of GnT-III, de-localization of E-cadherin and cytoplasmic accumulation, modification of N-glycosylation in E-cadherin |
703956 |
| 2.4.1.144 | down |
stimulation of the Wnt signaling pathway by the addition of exogenous Wnt3a or SB415286 consistently and significantly inhibits enzyme expression |
722734 |
| 2.4.1.144 | down |
the expression levels of GnT-III are suppressed about 25fold in transforming growth factor-beta-treated cells (5 ng/ml) |
722755 |
| 2.4.1.144 | up |
E-cadherin-mediated cell-cell interaction upregulates GnT-III expression, suggesting that regulation of GnT-III and E-cadherin expression may exist as a positive feedback loop |
703093 |
| 2.4.1.144 | up |
E-cadherin-mediated cell-cell interaction upregulates GnT-III expression. Significant upregulation of GnT-III expression in epithelial cells that express basal levels of E-cadherin and GnT-III |
702516 |
| 2.4.1.144 | up |
increase of enzyme expression by wild-type E-cadherin |
703956 |
