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Results 1 - 5 of 5
EC Number Expression Commentary Reference
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135down GlcAT-I promoter activity is suppressed by co-expression of calcineurin and nuclear factors of activated T cells 2, 3, and 4, treatment with WP631 at 50-100 nM completely abolishes ionomycin-mediated induction in GlcAT-I-D reporter activity as well as suppressing basal promoter activity 704645
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135up the enzyme is upregulated 3fold by 5 ng/ml transforming growth factor-beta1. Enzyme expression is increased in idiopathic pulmonary fibrosis, fibrotic rat lungs, and fibrotic lung fibroblasts 721257
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135up treatment with 0.001 mM ionomycin for 24 h results in increased GlcAT-I expression, ionomycin mediated induction of GlcAT-I promoter activity requires TonEBP binding to TonE, calcium regulates GlcAT-I expression in cells of the nucleus pulposus 704645
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135up treatment with both BMP-2 (200 ng/ml) and TGFbeta (10 ng/ml) for 24 h results in increased GlcAT-I mRNA levels in nucleus pulposus cells, however, simultaneous treatment of nucleus pulposus cells with TGFbeta and BMP-2 does not synergize GlcAT-I mRNA expression. GlcAT-I regulation is mediated through transcription factors AP1, Sp1, and TonEBP (NFAT5). Treatment with MAPK inhibitors blocks BMP-2 and TGFbeta induced GlcAT-I expression. p38delta is important in GlcAT-I activation 704774
Show all pathways known for 2.4.1.135Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.135up under hypoxic conditions (1% O2) there is an increase in enzyme expression both in nucleus pulposus cells and in N1511 chondrocytes. Suppression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha induces enzyme promoter activity and expression only in nucleus pulposus cells 721465
Results 1 - 5 of 5