EC Number   |
Expression |
Reference |
|---|
   2.1.1.67 | down |
decreased activity of TPMT is associated with hematopoietic toxicity after administration of standard doses of 6- mercaptopurine or azathioprine |
704818 |
| 2.1.1.67 | down |
the restriction of L-methionine in cell growth media reversibly decreases enzyme activity and protein levels |
718804 |
| 2.1.1.67 | more |
S-adenosyl-L-methionine has no effect on TPMT mRNA expression |
706092 |
| 2.1.1.67 | up |
azathioprine therapy can raise TPMT activity |
703355 |
| 2.1.1.67 | up |
longitudinal induction of thiopurine methyltransferase activity is observed during 6-thioguanine treatment |
701941 |
| 2.1.1.67 | up |
smokers have significantly higher TPMT activity than nonsmokers |
706092 |
| 2.1.1.67 | up |
TPMT activity is significantly higher in wild type children than in wild type adults (18-68 years), wild type infants from 0.08-5 years has a 9% higher average TPMT activity than the other wild type groups, only in children from 0.08-2 years is the TPMT activity higher in males than in females |
706093 |
