EC Number   |
Expression |
Reference |
|---|
    1.3.1.70 | down |
luteinizing hormone and follicle stimulating hormone both downregulates expression of 14-SR with the progression of antral follicular development |
713446 |
| 1.3.1.70 | down |
TM7SF2 gene expression is controlled by cell sterol levels through the SREBP-2, mutation of the SRE motif causes a dramatic decrease of transactivation by SREBP-2 |
711302 |
| 1.3.1.70 | down |
when cholesterol levels are high, enzyme gene expression is inhibited |
765069 |
| 1.3.1.70 | up |
2-amino-nonyl-6-methoxyl-tetralin muriate increases mRNA levels of sterol metabolism genes such as ERG24 |
723885 |
| 1.3.1.70 | up |
after CuSO4 is added to the medium, the mRNA level of the enzyme gene is dramatically induced by at least 6.5fold. Deletion of C-8 sterol isomerase (erg2) also induces the expression of the enzyme |
-, 764764 |
| 1.3.1.70 | up |
TM7SF2 gene expression is controlled by cell sterol levels through the SREBP-2, motifs of TM7SF2 promoter responsible for activation by SREBP-2 are the SRE motif, and both the inverted CCAAT-box and GC-box2, which are essential for full promoter activation by SREBP-2, overview. Binding of SREBP-2 to SRE produces approximately 26fold promoter activation |
711302 |
| 1.3.1.70 | up |
under conditions of low cholesterol, enzyme gene expression is up-regulated by SREBP-2 |
765069 |
