EC Number   |
Expression |
Reference |
|---|
   1.21.99.4 | down |
3,5,3'-triiodothyronine decreases mRNA levels in TT cell, addition of thyroxine or 3,3',5'-triiodothyronine decreases the deiodinating activity |
700176 |
| 1.21.99.4 | down |
caloric restriction decreases activity in white fat |
700655 |
| 1.21.99.4 | down |
decrease of liver type 1 deiodinase levels after infection only in wild-type mice, low expression levels in type 3 deiodinase knockout mice |
697632 |
| 1.21.99.4 | down |
decrease of pituitary type 2 deiodinase levels after infection |
697632 |
| 1.21.99.4 | down |
enzyme expression is significantly attenuated in all tissue homogenates of ovarectomized rats |
745617 |
| 1.21.99.4 | down |
expression of the Dio1 gene is dependent on HNF4alpha expression, the Dio1 promoter is directly regulated by HNF4alpha |
700153 |
| 1.21.99.4 | down |
substrate-dependent down-regulation, WSB-1-mediated ubiquitination inactivates the enzyme and targets it for proteasomal degradation, TEB4 interacts with the enzyme and mediates loss of activity and protein |
700172 |
| 1.21.99.4 | down |
the enzymatic activity of type 1 iodothyronine deiodinase is low in liver hemangioma |
713974 |
| 1.21.99.4 | more |
there is no significant difference between the thyroidal type 2 iodothyronine deiodinase mRNA level in patients with with 3,5,3'-triiodothyronine-predominant Graves' disease and that in patients with common type-Graves' disease |
714894 |
| 1.21.99.4 | up |
5'-deiodinase is increased in McCune-Albright syndrome-associated hyperthyroidism pathogenesis |
699169 |
