EC Number   |
Expression |
Reference |
|---|
   1.14.11.4 | down |
reduction of TIA protein levels in mous embryonic fibroblasts and HEK-293 cells leads to a corresponding decrease in the LH2(long) spliced product in both the minigene and the endogenous gene |
699401 |
| 1.14.11.4 | more |
LH activity of LH3 is not reduced by mutations of this DXD motif |
722865 |
| 1.14.11.4 | more |
no induction of PLOD3 expression in osteoblasts by DELTA9-tetrahydrocannabinol and cannabidiol |
745431 |
| 1.14.11.4 | up |
cannabidiol stimulates mRNA expression of Plod1 in primary osteoblast cultures |
745431 |
| 1.14.11.4 | up |
DELTA9-tetrahydrocannabinol stimulates mRNA expression of Plod2 in primary osteoblast cultures |
745431 |
| 1.14.11.4 | up |
gene expressions of isozymes LH1, LH2b and LOXL2 are significantly upregulated by 1,25(OH)2D3, the active form of vitamin D |
696018 |
| 1.14.11.4 | up |
highly expressed in lower-grade glioma tumor tissues compared to normal tissues |
764722 |
| 1.14.11.4 | up |
hypoxia upregulates PLOD2 protein in U87 and U251 human glioma cell lines. siRNA knockdown of endogenous HIF-1alpha or treatment of cells with the HIF-1alpha inhibitor PX-478 largely abolishes the hypoxia-mediated PLOD2 upregulation |
765490 |
| 1.14.11.4 | up |
hypoxia-inducible factor 1 activates transcription of the PLOD1 and PLOD2 genes in hypoxic breast cancer cells, knockdown of HIF-1a expression blocks PLOD1 and PLOD2 induction under hypoxic conditions |
725955 |
| 1.14.11.4 | up |
in osteoarthritic human synovial fibroblasts, the enzyme expression is induced by TGF-beta via kinase ALK5, not ALK1, and Smad2/3P |
724702 |
