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Search Expression

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EC Number	Expression	Commentary	Reference
1.1.1.357	down	R1881 treatment decreases AKR1C3 transcripts by about 1.5fold in Rv1 cells, AKR1C3 transcripts are androgen-repressed	740737
1.1.1.357	up	liver X receptor alpha binds specifically to the liver X receptor alpha response element and mediates transcriptional activation of the AKR1C4 gene. Liver X receptor ligand T1317 induces isoform AKR1C4 expression approximately 2.3fold	689076
1.1.1.357	up	the enzyme is induced in the presence of testosterone and progesterone due to the steroids preventing repressor repA from binding the regulatory regions	742260

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Release 2023.1 (January 2023)