EC Number |
Expression |
Reference |
---|
2.3.1.B41 | down |
SIRT6 is down-regulated in human glioma tissues |
729145 |
2.3.1.B41 | down |
H2O2 treatment significantly reduces Sirt6 protein. Stress-induced downregulation of Sirt6 is likely involved in the pathogenesis of diabetic retinopathy |
729362 |
2.3.1.B41 | up |
SIRT6 is upregulated in squamous cell carcinoma |
729520 |
2.3.1.B41 | down |
decline of SIRT6 expression when bladder cancer progresses from stage T2 to stage T4 |
729849 |
2.3.1.B41 | down |
in cortical and hippocampal neurons SIRT6 is downregulated during maturation in vitro, reaching the lowest expression at 11 days in vitro |
730473 |
2.3.1.B41 | up |
during mitosis, the Sirt6 expression level is increased |
730527 |
2.3.1.B41 | up |
enzyme expression in HCC cells is upregulated by transforming growth factor-beta1, H2O2, and HOCl |
737977 |
2.3.1.B41 | down |
enzyme expression is significantly reduced in human ovarian cancer tissues compared to the normal tissues |
738169 |
2.3.1.B41 | up |
SIRT6 expression is upregulated under pathologic conditions in angiotensin II-stimulated cardiac fibroblasts and in myocardium of rat subjected to abdominal aortic constriction surgery |
739733 |
2.3.1.B41 | up |
inhibition of SIRT5 significantly promotes SIRT6 expression |
755904 |