EC Number   |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
|---|
   5.4.99.47 | 748774 |
Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species |
New Phytol. |
218 |
1076-1088 |
2018 |
Oryza sativa Japonica Group |
29528490 |
| 5.4.99.47 | 748774 |
Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species |
New Phytol. |
218 |
1076-1088 |
2018 |
Oryza sativa Japonica Group Zhonghua 11 |
29528490 |
| 5.4.99.47 | 653405 |
Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis |
Org. Lett. |
4 |
4459-4462 |
2002 |
Arabidopsis thaliana |
12465912 |
| 5.4.99.47 | 715239 |
Directed evolution to investigate steric control of enzymatic oxidosqualene cyclization. An isoleucine-to-valine mutation in cycloartenol synthase allows lanosterol and parkeol biosynthesis |
J. Am. Chem. Soc. |
121 |
9887-9888 |
1999 |
Saccharomyces cerevisiae |
- |
| 5.4.99.47 | 714739 |
Histidine residue at position 234 of oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae simultaneously influences cyclization, rearrangement, and deprotonation reactions |
ChemBioChem |
6 |
1177-1181 |
2005 |
Saccharomyces cerevisiae |
15915534 |
| 5.4.99.47 | 713760 |
Oxidosqualene Cyclase Residues that Promote Formation of Cycloartenol, Lanosterol, and Parkeol We are grateful to Bridget M. Joubert for advice regarding mutagenesis. We thank Elizabeth A. Hart for an authentic parkeol standard, and for chromatographic and spectroscopic information. This research was funded by the National Institutes of Health (grant no. AI 41598) and the Robert A. Welch Foundation (grant no. C-1323). M.M.M. was an American Society of Pharmacognosy Undergraduate Fellow. M.J.R.S. was a Robert A. Welch Fellow and was supported by an NIH Biotechnology Training Grant (grant no. T32 GM08362). |
Angew. Chem. |
39 |
4090-4092 |
2000 |
Saccharomyces cerevisiae |
11093215 |
| 5.4.99.47 | 682344 |
Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes |
Plant Cell Physiol. |
47 |
673-677 |
2006 |
Lotus japonicus |
16531457 |
| 5.4.99.47 | 728425 |
Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase |
Org. Lett. |
14 |
5222-5225 |
2012 |
Saccharomyces cerevisiae |
23043506 |
| 5.4.99.47 | 714021 |
Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase |
Biochem. Biophys. Res. Commun. |
391 |
899-902 |
2010 |
Aspergillus fumigatus |
19951700 |
| 5.4.99.47 | 716421 |
Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases |
Org. Lett. |
13 |
2678-2681 |
2011 |
Oryza sativa |
21526825 |
