EC Number   |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
|---|
    1.14.14.32 | 745754 |
Anticancer activity of a novel selective CYP17A1 inhibitor in preclinical models of castrate-resistant prostate cancer |
Mol. Cancer Ther. |
14 |
59-69 |
2015 |
Homo sapiens |
25351916 |
| 1.14.14.32 | 745365 |
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1 |
J. Biol. Chem. |
292 |
13168-13185 |
2017 |
Homo sapiens |
28684414 |
| 1.14.14.32 | 695150 |
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites |
Steroids |
73 |
652-656 |
2008 |
Homo sapiens |
18355883 |
| 1.14.14.32 | 694117 |
17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response |
Mol. Cancer Ther. |
7 |
2828-2836 |
2008 |
Homo sapiens |
18790763 |
| 1.14.14.32 | 657657 |
5alpha-reduced C21 steroids are substrates for human cytochrome P450c17 |
Arch. Biochem. Biophys. |
418 |
151-160 |
2003 |
Homo sapiens |
14522586 |
| 1.14.14.32 | 726886 |
Active site proton delivery and the lyase activity of human CYP17A1 |
Biochem. Biophys. Res. Commun. |
443 |
179-184 |
2014 |
Homo sapiens |
24299954 |
| 1.14.14.32 | 727424 |
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17alpha-hydroxylase/C17,20-lyase |
Eur. J. Med. Chem. |
70 |
649-660 |
2013 |
Homo sapiens |
24211641 |
| 1.14.14.32 | 727424 |
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17alpha-hydroxylase/C17,20-lyase |
Eur. J. Med. Chem. |
70 |
649-660 |
2013 |
Rattus norvegicus |
24211641 |
| 1.14.14.32 | 694115 |
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer |
Mol. Cancer Ther. |
7 |
2348-2357 |
2008 |
Homo sapiens |
18723482 |
| 1.14.14.32 | 714352 |
At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17 |
Biochim. Biophys. Acta |
1814 |
200-209 |
2011 |
Papio sp. |
20619364 |
