EC Number   |
BRENDA No. |
Title |
Journal |
Volume |
Pages |
Year |
Organism |
PubMed ID |
|---|
    1.14.14.176 | 759822 |
Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana |
Nat. Commun. |
10 |
4850 |
2019 |
Taxus cuspidata |
31649252 |
| 1.14.14.176 | 743935 |
Engineering of taxadiene synthase for improved selectivity and yield of a key taxol biosynthetic intermediate |
ACS Synth. Biol. |
6 |
201-205 |
2017 |
Taxus sp. |
27794603 |
| 1.14.14.176 | 746375 |
Heterologous expression and characterization of plant taxadiene-5alpha-hydroxylase (CYP725A4) in Escherichia coli |
Protein Expr. Purif. |
132 |
60-67 |
2017 |
Taxus cuspidata |
28109855 |
| 1.14.14.176 | 743915 |
Mechanistic insights into taxadiene epoxidation by taxadiene-5alpha-hydroxylase |
ACS Chem. Biol. |
11 |
460-469 |
2016 |
Taxus cuspidata |
26677870 |
| 1.14.14.176 | 758950 |
Optimising the biosynthesis of oxygenated and acetylated taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies |
Biotechnol. Bioeng. |
118 |
279-293 |
2020 |
Taxus cuspidata |
32936453 |
| 1.14.14.176 | 743911 |
Orthogonal assays clarify the oxidative biochemistry of taxol P450 CYP725A4 |
ACS Chem. Biol. |
11 |
1445-1451 |
2016 |
Taxus brevifolia |
26930136 |
| 1.14.14.176 | 744544 |
Taxadiene-5alpha-ol is a minor product of CYP725A4 when expressed in Escherichia coli |
Biotechnol. Appl. Biochem. |
65 |
294-305 |
2018 |
Taxus cuspidata |
28876471 |
| 1.14.14.176 | 687790 |
CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the yclic ether 5(12)-oxa-3(11)-cyclotaxane |
J. Biol. Chem. |
283 |
6067-6075 |
2008 |
Taxus cuspidata |
18167342 |
| 1.14.14.176 | 658425 |
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis |
Chem. Biol. |
11 |
379-387 |
2004 |
Taxus cuspidata |
15123267 |
| 1.14.14.176 | 440286 |
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis |
Chem. Biol. |
3 |
479-489 |
1996 |
Taxus brevifolia |
8807878 |
