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EC Number
BRENDA No.
Title
Journal
Volume
Pages
Year
Organism
PubMed ID
2.1.1.224
705766
A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503
Mol. Microbiol.
57
1064-1073
2005
Escherichia coli
16091044
2.1.1.224
701724
The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics
Antimicrob. Agents Chemother.
50
2500-2505
2006
Escherichia coli
16801432
2.1.1.224
706726
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria
RNA
15
327-336
2009
Escherichia coli K-12
19144912
2.1.1.224
705983
Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria
Nucleic Acids Res.
38
1652-1663
2009
Escherichia coli
20007606
2.1.1.224
720968
High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics
Protein Expr. Purif.
74
204-210
2010
Azotobacter vinelandii
20678576
2.1.1.224
704203
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA
J. Am. Chem. Soc.
132
3953-3964
2010
Escherichia coli
20184321
2.1.1.224
758461
Structural basis for methyl transfer by a radical SAM enzyme
Science
332
1089-1092
2011
Staphylococcus aureus
21527678
2.1.1.224
716927
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases
Science
332
604-607
2011
Escherichia coli
21415317
2.1.1.224
718587
Low fitness cost of the multidrug resistance gene cfr
Antimicrob. Agents Chemother.
55
3714-3719
2011
Staphylococcus aureus
21646483
2.1.1.224
718587
Low fitness cost of the multidrug resistance gene cfr
Antimicrob. Agents Chemother.
55
3714-3719
2011
Staphylococcus aureus RN4220
21646483
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