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EC Number Reaction Commentary Reference
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate a model for the role of the catalytic triad in transferring nitrogen from Gln to Asp. An alternative catalytic mechanism is proposed, which obviates the participation of a histidine residue in the reaction 1699
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate Arg325 is involved in stabilization of a pentacovalent intermediate leading to the formation of beta-aspartyl-AMP 1701
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate hybrid uni uni bi ter ping pong Theorell-Chance mechanism where the glutaminase reaction occurs first and Asp binds to the enzyme before ATP in the sequential segment. Diphosphate is the first product released in the Theorell-Chance reaction, which is followed by the ordered release of AMP and Asn 1680
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate mechanism 649482
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate NH4+ is bound to the enzyme followed by MgATP causing Asn release 1684
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate overall ping-pong mechanism -
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate ping-pong reaction mechanism. Glutamine is the first substrate to bind to the enzyme and Asn is the last product released -
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate reaction mechanism, structure-function relationship 745375
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate the enzyme forms a crucial beta-aspartyl-AMP-Mg2+ intermediate, which then undergoes a nucleophilic attack of ammonia, forming Asn and releasing AMP and diphosphate. Ammonia can be free or glutamine-derived -, 746172
Show all pathways known for 6.3.5.4Display the word mapDisplay the reaction diagram Show all sequences 6.3.5.4ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate uni-uni-bi-ter ping-pong mechanism without abortive complexes. Gln binds first, followed by Glu release, and Asp and ATP bind in order followed by ordered release of diphosphate, AMP and Asn. In the presence of 0.5-2.0 mM excess Mg2+ over ATP the binding of substrates after the release of Glu is in a rapid equilibrium system 1673
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