EC Number   |
Reaction |
Reference |
|---|
    6.3.3.3 | ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin |
8-aminocarbamate of (7R,8S)-7,8 diaminononanoate is an enzyme-bound intermediate |
1349 |
| 6.3.3.3 | ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin |
enzyme reaction involves three steps: carbamylation of theN7 position of 7,8-diaminononanoate, formation of a carbamate-phosphoric anhydride intermediate, and, closure of the ureido ring to form dethiobiotin and release of the inorganic phosphate |
714208 |
| 6.3.3.3 | ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin |
mechanistic model in which binding of Mg2+ and the triphosphate element of ATP to the enzyme creates the appropriate geometry for substrate 7,8-diaminononanoate-binding and carbamate formation |
1346 |
| 6.3.3.3 | ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin |
the carbonylation of 7,8-diaminononanoic acid proceeds regiospecifically via the N7-carbamate |
1340, 1343 |
| 6.3.3.3 | ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin |
the final intermediate is the phosphoric acid anhydride of the carbamate |
1348 |
