6.2.1.25 | ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA |
ATP-dependent, two-step mechanism of a benzoate:CoA ligase in the presence of magnesium, overview. The enzyme follows a mechanism that involves substrate binding in the thiolation conformation, followed by substrate rotation to an active orientation upon the transition to the adenylation conformation |
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