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EC Number Reaction Commentary Reference
Show all pathways known for 6.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.7ATP + L-alanine + tRNAAla = AMP + diphosphate + L-alanyl-tRNAAla - -
Show all pathways known for 6.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 6.1.1.7ATP + L-alanine + tRNAAla = AMP + diphosphate + L-alanyl-tRNAAla kinetic mechanism, AlaRS belongs to the class II of aminoacyl-tRNA ligases due to the position of aminoacylation on the 3'-terminal tRNA ribose, and the topology and tRNAbinding orientation of the active-site protein fold, class II synthetases are rate-limited by a step prior to aminoacyl transfer, the distinct mechanistic signatures of class I versus class II tRNA synthetases ensure rapid turnover of aminoacyl-tRNAs during protein synthesis 675395
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