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EC Number	Reaction	Commentary	Reference
4.4.1.22	S-(hydroxymethyl)glutathione = glutathione + formaldehyde	GSH reacts with HCHO via its nucleophilic thiol group to form the intermediate S-hydroxymethylglutathione (HMG). The catalysis of enzyme glutathione-dependent formaldehyde-activating enzyme (GFA) is proposed to proceed via a highly unusual mechanism involving translocation of this second zinc ion to another undefined site on the protein. HMG formation is subsequently catalysed at this site before the zinc ion returns to the trigonal planar site after catalysis	749071
4.4.1.22	S-(hydroxymethyl)glutathione = glutathione + formaldehyde	the enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway	656068

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Release 2023.1 (January 2023)