4.3.1.24 | L-phenylalanine = trans-cinnamate + NH3 |
analysis of active-site structure analysis and reaction mechanism in which the amino group of the phenylalanine substrate is attacked directly by the 4-methylidene-imidazole-5-one prosthetic group, the reaction proceeds through a carbanion intermediate, Tyr78 acts as a general base, helix-to-loop conformational switch in the helices flanking the inner active-site loop that regulates accessibility of the active site, modeling, overview |
693649 |