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Results 1 - 8 of 8
EC Number Reaction Commentary Reference
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 an active site base is essential for activity, and alpha-deuterated substrate exhibits modest primary isotope effects on kcat and kcat/Km, suggesting that substrate deprotonation is partially rate-limiting. Pre-steady state kinetics with enzyme TPL show rapid formation of external aldimine intermediate, followed by deprotonation to give a quinonoid intermediate absorbing at about 500 nm. The mechanism of TPL requires both substrate strain and acid/base catalysis, and substrate strain is probably responsible for the very high substrate specificity of TPL. Acid-base catalysis mechanism of TPL, overview 747245
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 mechanism 33453, 33467, 649731, 650039, 650407, 651062, 651086, 652265, 653702
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 mechanism appears to require two bases, one of which abstracts the proton from the 2-position of the substrate to form a quinonoid intermediate and the second of which acting in concert with proton transfer from the first group to C-1 of the phenolic ring, abstracts the substrate hydroxyl group to facilitate cyclohexadienone formation and subsequent elimination of phenol 33441
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 mechanism of alpha,beta-elimination of L-tyrosine catalyzed by enzyme TPL 746892
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 mechanism of alpha,beta-elimination of L-tyrosine catalyzed by enzyme TPL, detailed overview 746580
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 NH3 is the first substrate which interacts with bound pyridoxal 5'-phosphate, pyruvate is the second substrate 33447
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 reversible cleavage of the Cbeta-Cgamma bond of L-tyrosine in the final stage of the beta-elimination, via intermediates: internal aldimine, external aldimine, quinoid, ketoquinoid, alpha-aminoacrylate, and internal aldimine, stepwise mechanism, overview 727663
Show all pathways known for 4.1.99.2Display the word mapDisplay the reaction diagram Show all sequences 4.1.99.2L-tyrosine + H2O = phenol + pyruvate + NH3 single-base racemization mechanism, proceeds with retention of configuration at C-beta 33444
Results 1 - 8 of 8