EC Number   |
Reaction |
Reference |
|---|
   3.8.1.10 | (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide |
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining) |
- |
| 3.8.1.10 | (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide |
group I enzymes, including DL-2-haloacid dehalogenase and D-2-haloacid dehalogenase, catalyze the reaction without forming an ester intermediate. Instead, a solvent water molecule directly attacks the alpha-carbon atom of the substrate to release the halide ion. DL-2-haloacid dehalogenase acts on both enantiomers of the substrate |
733212 |
| 3.8.1.10 | (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide |
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining) |
- |
| 3.8.1.10 | (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide |
group I enzymes, including DL-2-haloacid dehalogenase and D-2-haloacid dehalogenase, catalyze the reaction without forming an ester intermediate. Instead, a solvent water molecule directly attacks the alpha-carbon atom of the substrate to release the halide ion. DL-2-haloacid dehalogenase acts on both enantiomers of the substrate |
733212 |
