EC Number |
Reaction |
Reference |
---|
3.4.23.46 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
enzyme is an aspartic protease but is atypical in containing a C-terminal membrane-spanning domain |
638908 |
3.4.23.46 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
mechanism for enzyme regulation |
638914 |
3.4.23.46 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
memapsin 1 and 2 have overlapping yet distinct sequence preference |
638909 |
3.4.23.46 | broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein |
suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease |
638909 |