EC Number   |
Reaction |
Reference |
|---|
   3.4.21.118 | cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys |
enzyme is a trypsin-type serine protease |
647321, 647323, 647324, 647325, 647326, 647329 |
| 3.4.21.118 | cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys |
kallikrein k8 exhibit a marked preference for cleavage downstream of Arg residues |
647331 |
| 3.4.21.118 | cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys |
substrate binding pocket contains an Asp residue |
647332 |
| 3.4.21.118 | cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys |
substrate binding site structure defining the specificity for Arg and Lys in the S1 pocket |
647325 |
| 3.4.21.118 | cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys |
the ordered kallikrein loop projects proline towards the active site to restrict smaller residues or proline at the P2 position of substrates |
647325 |
