EC Number   |
Reaction |
Reference |
|---|
   3.4.21.104 | Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) |
- |
- |
| 3.4.21.104 | Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) |
catalytic serine residue is located on the light chain subunit |
659609 |
| 3.4.21.104 | Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) |
mechanism |
650997 |
| 3.4.21.104 | Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) |
structure-function analysis of the catalytic unit, enzyme-substrate interaction is different from enzyme C1 which has the same substrate specificity, MASP-2 shows a subsite flexibility in substrate specificity, catalytic residues are Asp526 and His525, active site structure, overview |
659718 |
| 3.4.21.104 | Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) |
substrate recognition mechanism, mechanism of complement cascade activation |
659350 |
