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Results 1 - 8 of 8
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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine catalytic mechanism -, 646932, 646933, 646940, 646952, 646954
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine chemical reaction mechanism, overview. For the catalysis to occur, the damaged base must be extruded from the DNA helix and placed in the active site of enzyme, this is achieved in Fpg by kinking DNA at the lesion point. The reaction mechanism involves coupled conformational changes in the enzyme and DNA, which proceed sequentially and assemble the catalytic groups in the active site 710030
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine formation of the transition state complex from the reactants exhibits an overall free energy of 9.6 kcal/mol 682591
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine kinetic mechanism 646952
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine mechanism -, 646938, 646948, 646950, 646951
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine reaction mechanism 646953
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine several fast sequential conformational changes occur in enzyme after binding to its substrate, converting the protein into a catalytically active conformation 670426
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.23DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine the damaged base is first destabilized by the enzyme binding and then everted from DNA, followed by insertion of several amino acid residues into DNA and isomerization of the enzyme into a pre-excision complex 678270
Results 1 - 8 of 8
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