EC Number   |
Reaction |
Reference |
|---|
    2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
catalytic mechanism, the first step of the mechanism is proposed to involve a nucleophilic attack of the NiI active state, MCRred1, on Me-SCoM to form a NiIII-methyl intermediate, spectroscopic analysis and structures, overview |
704208 |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
ethyl CoM and difluoromethyl CoM are poor substrates. The sulfide sulfur can be replaced by selenium but not by oxygen |
- |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
in the active site region of both isozymes, five modified amino acids occur determined by mass spectrometry: thioglycine alpha445, forming a thioxo peptide/thioamide bond with tyrosine alpha446, S-methylcysteine alpha452, 2-(S)-methylglutamine alpha400, 1-N-methylhistidine alpha257 and 5-(S)-methylarginine alpha271 |
673602 |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
in the active site region of both isozymes, modified amino acids occur determined by mass spectrometry: thioglycine alpha445, forming a thioxo peptide/thioamide bond with tyrosine alpha446, 2-(S)-methylglutamine alpha400, 1-N-methylhistidine alpha257 and 5-(S)-methylarginine alpha271 |
673602 |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
in the active site region of both isozymes, modified amino acids occur determined by mass spectrometry: thioglycine alpha445, forming a thioxo peptide/thioamide bond with tyrosine alpha446, S-methylcysteine alpha452, 1-N-methylhistidine alpha257 and 5-(S)-methylarginine alpha271 |
673602 |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
in the active site region of both isozymes, modified amino acids occur determined by mass spectrometry: thioglycine alpha445, forming a thioxo peptide/thioamide bond with tyrosine alpha446, S-methylcysteine alpha452, 2-(S)-methylglutamine alpha400, and 1-N-methylhistidine alpha257 |
673602 |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
in the active site region of both isozymes, modified amino acids occur determined by mass spectrometry: thioglycine alpha445, forming a thioxo peptide/thioamide bond with tyrosine alpha446, S-methylcysteine alpha452, 2-(S)-methylglutamine alpha400, and 5-(S)-methylarginine alpha271 |
673602 |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
mechanism, nucleophilic attack of Ni(I)-MCRred1 on the methyl group of methyl-SCoM generates a methyl-Ni intermediate |
672222 |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
methylreductase complex mechanism suggested |
- |
| 2.8.4.1 | methyl-CoM + CoB = CoM-S-S-CoB + methane |
proposed reaction mechanism uses a radical intermediate and a nickel organic compound. Suggested solutions for enzyme state, structure, reaction cycle and binding mechanism for the enzyme are given |
393246 |
