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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') catalytic mechanism of cyclic GMP-AMP synthase (cGAS). AMP-2'-GTP is produced in significant abundance initially, while 2',3'-cGAMP is not suggesting a mechanism where the majority of substrate flows through AMP-2'-GTP, which is released to solution and then must rebind in competition with ATP and GTP to form 2',3'-cGAMP. AMP-2'-GTP is not subject to ATP or GTP competition 762338
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') overall reaction -
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86ATP + GTP = pppGp(2'-5')A + diphosphate (1a) -
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate (1b) -
Results 1 - 4 of 4
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