EC Number |
Reaction |
Reference |
---|
2.7.7.60 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol |
conformational change of P-loop in the catalysis, concerted movements of the P-loop and L2-loop may be essential during the catalytic reaction, modeling |
-, 762421 |
2.7.7.60 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol |
cytidyltransferase family. Active substrate site consists of a glycine-rich loop spanning Pro13-Arg20. Three-dimensional structure of enzyme is figured out |
393240 |
2.7.7.60 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol |
IspD of Escherichia coli (EcIspD) follows stereochemical principles underlying the catalysis mechanism |
762421 |
2.7.7.60 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol |
no kinetic evidence for substrate channelling |
672138 |
2.7.7.60 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol |
ordered sequential mechanism |
661089 |
2.7.7.60 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol |
The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis |
- |
2.7.7.60 | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol |
third step in MEP pathway, isoprenoid biosynthesis |
-, 692926 |