EC Number |
Reaction |
Reference |
---|
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
active site nucleophil H166 |
642842, 642848, 642863 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
active site structure, enzyme complexed with UDP-galactose |
642860, 642863 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
active site triad: His164, His165, and His166, with His166 as nulceophilic catalyst, highly conserved |
642858, 642863 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
active site: C160SNPHP165 |
642863 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
amino acid residues of both subunits contribute to the active site |
642848 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
double-displacement mechanism |
642824, 642838, 642849, 642858, 642860 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
formation of a stable nucleotidylated histidine intermediate |
642849, 642863 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
Gln168 engages hydrogen bonding with the phosphoryl oxygen of the UMP moiety in the covalently formed reaction intermediate UMP-enzyme, UMP is bound to His166 |
642849, 642857, 642863 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
mechanism model |
642849 |
2.7.7.12 | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose |
mechanism, modeling |
642845 |