EC Number |
Reaction |
Reference |
---|
2.5.1.6 | ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine |
catalysis of a SN2 reaction through hydrogen bonding of the liberated oxygen-5' to the histidine, charge neutralization by the two Mg2+ ions, and stabilization of the product sulfonium cation through a close, non-bonded, contact between the sulfur and the ribose oxygen-4' |
701932 |
2.5.1.6 | ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine |
mechanism |
639038 |
2.5.1.6 | ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine |
mechanism of inhibiton by product analogues and implications for reaction |
658062 |
2.5.1.6 | ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine |
mechanism, key role of K182 in the correct positioning of the substrates, and D135 in stabilizing the sulfonium group formed in the product |
659701 |
2.5.1.6 | ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine |
neutral H14 acts as an acid to cleave the C5-O5 bond of ATP, S of methionine makes a nucleophilic attack on the C5 to form the product |
658053 |
2.5.1.6 | ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine |
steady state ordered Bi Ter mechanism with ATP adding before L-methionine and S-adenosylmethionine being the first product released, random release of phosphate and diphosphate |
639052 |